Author(s):
Sachee Khairnar, Jadhav Gauri, Vijay V. Shewale, Sunik Mahajan, Dipak Sonawane
Email(s):
sacheekhairanar@gmail.com
DOI:
10.52711/0975-4385.2026.00056 
Address:
Sachee Khairnar, Jadhav Gauri, Vijay V. Shewale, Sunik Mahajan, Dipak Sonawane
Department of Pharmacognosy, Divine College of Pharmacy, Satana, Dist. Nashik, Savitribai, Phule Pune University, Pune 411007, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 4,
Year - 2026
ABSTRACT:
Insulin resistance and chronic hyperglycemia are the main causes of type 2 diabetes mellitus (T2DM), a significant global health concern. Nutraceuticals made from traditional herbs and spices have garnered a lot of attention lately due to their potential for managing diabetes and regulating metabolism. This analysis highlights the bioactive components and antidiabetic qualities of four commonly used culinary powders: fenugreek, cinnamon, ginger, and cardamom. Soluble fibre and 4-hydroxyisoleucine, which promote glycaemic management and insulin sensitivity, are abundant in fenugreek. Cinnamonaldehyde and associated compounds found in cinnamon may increase insulin receptor activation and promote the absorption of glucose. Because of its anti-inflammatory and antioxidant properties, ginger improves insulin secretion and lowers oxidative stress. Although it has not been studied as much, cardamom has the potential to reduce blood glucose and modify lipid metabolism. When taken as a whole, these nutraceutical powders show promise as supplemental dietary approaches for managing and preventing type 2 diabetes. However, additional carefully planned clinical trials are necessary to verify their therapeutic efficacy, identify the best doses, and create safety profiles.
Cite this article:
Sachee Khairnar, Jadhav Gauri, Vijay V. Shewale, Sunik Mahajan, Dipak Sonawane. A Review on Role of Nutraceutical Powders in Prevention of Type 2 Diabetes Mellitus. Research Journal of Pharmacognosy and Phytochemistry. 2026; 18(4):393-6. doi: 10.52711/0975-4385.2026.00056
Cite(Electronic):
Sachee Khairnar, Jadhav Gauri, Vijay V. Shewale, Sunik Mahajan, Dipak Sonawane. A Review on Role of Nutraceutical Powders in Prevention of Type 2 Diabetes Mellitus. Research Journal of Pharmacognosy and Phytochemistry. 2026; 18(4):393-6. doi: 10.52711/0975-4385.2026.00056 Available on: https://www.rjpponline.org/AbstractView.aspx?PID=2026-18-4-12
REFERENCES:
1. Olo.koba AB, Obateru OA, Olokoba LB. Type 2 diabetes mellitus: a review of current trends. Oman Medical Journal. 2012 Jul; 27(4): 269.
2. Bellou V, Belbasis L, Tzoulaki I, Evangelou E. Risk factors for type 2 diabetes mellitus: an exposure-wide umbrella review of meta-analyses. PloS one. 2018 Mar 20; 13(3): e0194127.
3. Cepeda F, Kerner T, Nowakowska B, Birhan F, Zghebi H, Kempegowda H, Malek A. Systematic Review of Type 2 Diabetes: Chronic Metabolic Disorder, J. International Journal of Endocrinology and Disorders. 2024; 2.
4. Blahova J, Martiniakova M, Babikova M, Kovacova V, Mondockova V, Omelka R. Pharmaceutical drugs and natural therapeutic products for the treatment of type 2 diabetes mellitus. Pharmaceuticals. 2021 Aug 17; 14(8): 806.
5. Chaudhary S, Chaudhary PS, Chikara SK, Sharma MC, Iriti M. Review on fenugreek (Trigonella foenum-graecum L.) and its important secondary metabolite diosgenin. Notulae Botanicae Horti Agrobotanici Cluj-Napoca. 2018 Jan 1; 46(1): 22-31.
6. Haxhiraj M, White K, Terry C. The role of fenugreek in the management of type 2 diabetes. International journal of molecular sciences. 2024 Jun 26; 25(13): 6987.
7. Mossa JS. A study on the crude antidiabetic drugs used in Arabian folk medicine. International Journal of Crude Drug Research. 1985 Jan 1; 23(3): 137-45.
8. Mane K, Patil R, Burungale S. Effect of Fenugreek Supplementation in Diabetes.
9. Broca C, Manteghetti M, Gross R, Baissac Y, Jacob M, Petit P, Sauvaire Y, Ribes G. 4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion. European Journal of Pharmacology. 2000 Mar 3; 390(3): 339-45.
10. Kawatra P, Rajagopalan R. Cinnamon: Mystic powers of a minute ingredient. Pharmacognosy research. 2015 Jun; 7(Suppl 1): S1.
11. Dukre TP, Wadekar GN, Unde AN, Pawar HB. Pharmacognostic evaluation and physicochemical screening of the rhizomes of Zingiber officinale (Ginger). Journal of Pharmacognosy and Phytochemistry. 2023; 12(5): 51-4.
12. Ismail BS, Mahmoud B, Abdel-Reheim ES, Soliman HA, Ali TM, Elesawy BH, Zaky MY. Cinnamaldehyde Mitigates Atherosclerosis Induced by High‐Fat Diet via Modulation of Hyperlipidemia, Oxidative Stress, and Inflammation. Oxidative Medicine and Cellular Longevity. 2022; 2022(1): 4464180.
13. Satapati S. Bifurcation of in vivo hepatic energy metabolism and glucose production in insulin resistance and diabetes.
14. Ijaz S, Iqbal J, Abbasi BA, Ullah Z, Uddin S, Yaseen T, Zarshan F, Ali H, Sher H, Ullah Z, Ali A. Bioactive Phytochemicals from Ginger (Zingiber officinale) By-products. InBioactive Phytochemicals in By-products from Leaf, Stem, Root and Tuber Vegetables 2025 Mar 22 (pp. 281-303). Cham: Springer Nature Switzerland.
15. Ashokkumar K, Murugan M, Dhanya MK, Warkentin TD. Botany, traditional uses, phytochemistry and biological activities of cardamom [Elettaria cardamomum (L.) Maton]–A critical review. Journal of ethnopharmacology. 2020 Jan 10; 246:112244.
16. El Azab EF, Mostafa HS. Geraniol ameliorates the progression of high fat‐diet/streptozotocin‐induced type 2 diabetes mellitus in rats via regulation of caspase‐3, Bcl‐2, and Bax expression. Journal of Food Biochemistry. 2022 Jul; 46(7): e14142.
17. Kalra EK. Nutraceutical-definition and introduction. Aaps Pharmsci. 2003 Sep; 5(3): 25.
18. Sathya SS, Sudha T. Herbal Drug Technology. 1st ed. Chennai: Pee Vee Publications; 2020.
19. Gaddam A, Galla C, Thummisetti S, Marikanty RK, Palanisamy UD, Rao PV. Role of Fenugreek in the prevention of type 2 diabetes mellitus in prediabetes. Journal of Diabetes & Metabolic Disorders. 2015 Oct 2; 14(1): 74.
20. Kim J, Noh W, Kim A, Choi Y, Kim YS. The effect of fenugreek in type 2 diabetes and prediabetes: a systematic review and meta-analysis of randomized controlled trials. International journal of molecular sciences. 2023 Sep 12; 24(18): 13999.
21. Qin B, Panickar KS, Anderson RA. Cinnamon: potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes. Journal of diabetes science and technology. 2010 May; 4(3): 685-93.
22. Allen RW, Schwartzman E, Baker WL, Coleman CI, Phung OJ. Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis. The Annals of Family Medicine. 2013 Sep 1; 11(5): 452-9.
23. Breitscheidel L, Stamenitis S, Dippel FW, Schöffski O. Economic impact of compliance to treatment with antidiabetes medication in type 2 diabetes mellitus: a review paper. Journal of medical economics. 2010 Mar 1; 13(1): 8-15.
24. DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, Hu FB, Kahn CR, Raz I, Shulman GI, Simonson DC. Type 2 diabetes mellitus. Nature reviews Disease primers. 2015 Jul 23; 1(1): 1-22.
25. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes care. 2013 Jan 1; 36(Supplement_1): S67-74.
26. Coppola A, Sasso L, Bagnasco A, Giustina A, Gazzaruso C. The role of patient education in the prevention and management of type 2 diabetes: an overview. Endocrine. 2016 Jul; 53(1): 18-27.
27. Zeru MA, Tesfa E, Mitiku AA, Seyoum A, Bokoro TA. Prevalence and risk factors of type-2 diabetes mellitus in Ethiopia: systematic review and meta-analysis. Scientific reports. 2021 Nov 5; 11(1): 21733.